This study shows TGF-beta signaling suppresses epithelial permeability in Drosophila ovaries by enhancing E-Cadherin adhesion, independent of actomyosin contractility.

DOI 10.64898/2026.02.14.705893

Drosophilastatistical model

𝕏 PostBluesky

Developmental BiologybioRxivPreprintOct 4, 2024

Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions restricts epithelial permeability in Drosophila

Thea Jacobs, Jone Isasti Sanchez, Steven Reger, Stefan Luschnig

The paper shows that Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions controls epithelial permeability in Drosophila by modulating vertex tension.

DOI 10.1101/2024.10.04.616625

Drosophilastatistical model

𝕏 PostBluesky

Developmental BiologyJournal of Cell SciencePeer-reviewedJan 12, 2022

Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies

Carolina Camelo, Anna Körte, Thea Jacobs, Stefan Luschnig

The paper identifies Stac-positive extracellular vesicles derived from multivesicular bodies that mediate tracheal tube fusion in Drosophila embryos through the action of Arl3, Rab27, and Rab35.

17 citations

Drosophilaexperimental assay

𝕏 PostBluesky