Jennifer S. Lanni

This study characterizes macrodactyly, a localized overgrowth disorder, by linking it to somatic mosaic PIK3CA mutations and demonstrating nerve and vascular regulation of growth through a novel animal model.

The paper identifies genetic regulators of fin proportion in flying fish through comparative genomics and zebrafish mutants, revealing a conserved signaling pathway involving amino acid transport and potassium channels.

The paper identifies a zebrafish mutant with proportional overgrowth due to Kcc4a loss of function and shows its role in bioelectric signaling for growth regulation.

The paper identifies kcnk5b as a key regulator of allometric growth in zebrafish fins by integrating calcineurin signaling.