Author

Brian I. Labow

Boston Children's HospitalORCID 0000-0002-7568-8634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Catherine T. McNamara· 2 shared Laura C. NuzziiD· 2 shared Anh Phuong LeiD· 1 shared Carl A. Nist-LundiD· 1 shared David S. Peal· 1 shared Edward H Lee· 1 shared Ian A. GlassiD· 1 shared Jake Daane· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersDevelopmental Biology

Catherine T. McNamara

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2 papers

Recent·Most cited

Lateral plate mesoderm directs human amnion and ventral skin organoid formation

Anh Phuong Le, Jin Kim, Qianyi Ma, Kelly Y Gim, Sara A. Serdy, Edward H Lee, Shariqa T Shaila, Taiki Nakajima, Carl A. Nist-Lund, Ian A. Glass, Yosuke Mai, Laura C. Nuzzi, Catherine T. McNamara, Brian I. Labow, Liang Sun, , Karl R. Koehler

This study generates human ventral skin and amnion-like organoids by adjusting signaling and cellular composition, revealing key developmental pathways and interactions.

bioRxiv · Nov 5, 2025 · PreprintDevelopmental Biology

Characterization of coordinated growth in macrodactyly caused by somatic mosaic activating mutations in PIK3CA

Catherine T. McNamara, Jennifer S. Lanni, Jake Daane, Laura C. Nuzzi, David S. Peal, Matthew P. Harris, Brian I. Labow

This study characterizes macrodactyly, a localized overgrowth disorder, by linking it to somatic mosaic PIK3CA mutations and demonstrating nerve and vascular regulation of growth through a novel animal model.

medRxiv · Jun 7, 2022 · PreprintGenetic & Genomic Medicine