Hepatoblast iterative apicobasal polarization is regulated by extracellular matrix remodeling
Julien Delpierre, José Ignacio Valenzuela, Matthew J. Bovyn, Nuno Pimpão Martins, Lenka Belicová, Urška Repnik, Maarten P. Bebelman, Sarah Seifert, Pierre A. Haas, Yannis L. Kalaidzidis, Marino Zerial
The paper identifies a new mechanism of hepatoblast polarization during liver development, showing that ECM remodeling and cell-autonomous processes drive multiaxial polarity and lumen formation.
bioRxiv · Jan 30, 2024 · PreprintDevelopmental Biology