Yannis L. Kalaidzidis

The paper uses multi-omics approaches to study post-translational changes in macrophages during activation, identifying endosomal mRNA transport as a target of inflammation.

This study shows that the Villin-SNAP25 interaction regulates insulin secretion by controlling secretory granule docking sites in response to glucose levels.

This study identifies RAB14-dependent tubulovesicular recycling as a mechanism for MET delivery to invadopodia, enhancing TNBC cell invasion through matrix degradation.

This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.

TiMiGNet reconstructs 3D tissue microstructure across species using GANs, enabling high-resolution predictions without paired images.

This study shows that hepatocyte differentiation requires anisotropic expansion of bile canaliculi, with loss of polarity leading to cholangiocyte-like gene expression.

The paper identifies a new mechanism of hepatoblast polarization during liver development, showing that ECM remodeling and cell-autonomous processes drive multiaxial polarity and lumen formation.

The paper investigates how the acto-myosin system regulates YAP activity during liver regeneration in response to bile acid overload.