Marino Zerial

Chemical proteomics reveals post-translational remodeling of endosomal pathways during macrophage activation.

The paper uses multi-omics approaches to study post-translational changes in macrophages during activation, identifying endosomal mRNA transport as a target of inflammation.

Virtual tissue microstructure reconstruction across species using generative deep learning

TiMiGNet reconstructs 3D tissue microstructure across species using GANs, enabling high-resolution predictions without paired images.

Hepatocyte differentiation requires anisotropic expansion of bile canaliculi

This study shows that hepatocyte differentiation requires anisotropic expansion of bile canaliculi, with loss of polarity leading to cholangiocyte-like gene expression.

Hepatoblast iterative apicobasal polarization is regulated by extracellular matrix remodeling

The paper identifies a new mechanism of hepatoblast polarization during liver development, showing that ECM remodeling and cell-autonomous processes drive multiaxial polarity and lumen formation.

Metabolic control of YAP via the acto-myosin system during liver regeneration

The paper investigates how the acto-myosin system regulates YAP activity during liver regeneration in response to bile acid overload.

Content-Aware Image Restoration: Pushing the Limits of Fluorescence Microscopy

This paper demonstrates how deep learning-based image restoration extends fluorescence microscopy's capabilities by improving resolution, reducing photon exposure, and increasing frame rates.