Robert West

Asymmetric co-substrate usage at a metabolic branch point as a minimal network motif that can drive overflow metabolism

The paper identifies asymmetric co-substrate usage at a metabolic branch point as a mechanism that enables flux switching and drives overflow metabolism, validated through modeling and experimental data in yeast.

Co-substrate pools can constrain and regulate pathway fluxes in cell metabolism

The paper develops a mathematical framework to show co-substrate cycling imposes flux limits in metabolic pathways and demonstrates this using simulations and existing metabolic data.