Author

Karen Leal-Fischer

Centre National de la Recherche ScientifiqueORCID 0000-0001-9366-1294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:electrophysiology· 2 Organism:human· 2 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Jochen LangiD· 2 shared Julien GaitaniD· 2 shared Marie LallouetiD· 2 shared Matthieu RaouxiD· 2 shared Antoine PirogiD· 1 shared Aude ZimmermanniD· 1 shared Daniel T. MeieriD· 1 shared Emilie PuginieriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPhysiology

Jochen LangORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PhysiologyScience AdvancesPeer-reviewedJul 3, 2026

Pancreatic α-cells are required for nutrient homeostasis by regulating dynamic β-cell networks in islets

Marie Lallouet, Manon Jaffredo, Antoine Pirog…·Jochen Lang

This study shows that pancreatic α-cells regulate β-cell network dynamics to maintain nutrient homeostasis, even without metabolic stress.

1 citationtop 4%

mouseelectrophysiology

Cell BiologybioRxivPreprintMay 13, 2026

Desmoglein-3 modulates p38MAPK and ERK signaling responses through the mechano-sensitive channel Piezo1

Karen Leal-Fischer, Henriette Franz, Katarzyna Buczak…·Volker Spindler

This study shows DSG3 modulates p38MAPK and ERK signaling through Piezo1 in keratinocytes under mechanical stress.

DOI 10.64898/2026.05.11.723746

humanproteomics

Cell BiologyFrontiers in EndocrinologyPeer-reviewedMay 31, 2024

Extracellular electrophysiology on clonal human beta-cell spheroids

Emilie Puginier, Karen Leal-Fischer, Julien Gaitan…·Jochen Lang

This study shows that clonal human beta-cell spheroids enhance electrical activity and hormone secretion compared to monolayers, suggesting they are better models for studying beta-cell function.

7 citations