Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis
Nikolaj Pagh Kristensen, Natasja W Ettienne, Lasse Frank Voss, Amalie Kai Bentzen, Marina Rode von Essen, Tripti Tamhane, Finn Thorup Sellebjerg, Sine Reker Hadrup
The paper identifies HLA-specific depletion of CD8 T-cell responses to EBV and neuroantigens in MS patients, revealing immunophenotypic differences between MS and healthy donors.
bioRxiv · Oct 23, 2025 · PreprintImmunology