Nikolaj Pagh Kristensen

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity

The paper identifies an EBV-specific T cell program in MS patients that contributes to CNS autoimmunity through B cell and myeloid cell activation.

ITRAP2, a flexible and robust strategy to assign antigen recognition of T-cells in a coupled single-cell TCR-pMHC assay

ITRAP2 improves TCR-pMHC pairing accuracy by reducing noise and cross-contamination in single-cell data, outperforming existing methods on both in-house and public datasets.

Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis

The paper identifies HLA-specific depletion of CD8 T-cell responses to EBV and neuroantigens in MS patients, revealing immunophenotypic differences between MS and healthy donors.

Development of antigen-dextramers for detection and evaluation of CAR T cells

This paper develops antigen-dextramers to stain and functionally assess CAR T cells, showing they enable both detection and activation analysis with adjustable antigen density.

Antigen receptor competition in CAR-TCR cells changes cytotoxicity outcomes upon spatial antigen separation

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.