Author

Cassandra Litchfield

University Hospital ZurichORCID 0000-0001-9374-1681Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Holger MochiD· 2 shared Marija BuljaniD· 2 shared András KristoniD· 1 shared Andreas N. WICKIiD· 1 shared Bettina SobottkaiD· 1 shared Burkhard BecheriD· 1 shared Dorothea RutishauseriD· 1 shared Ede MighiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioinformatics

Holger MochORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 17, 2025

RIPPLET: Mutation-Only Gene and Pathway Profiling for Precision Oncology

Fabius Wiesmann, Cassandra Litchfield, Maud Mayoux…·Bettina Sobottka

RIPPLET converts somatic DNA variants into gene-impact scores and pathway-perturbation profiles, outperforming multi-omic tools in identifying cancer drivers and predicting drug response without RNA data.

DOI 10.1101/2025.09.17.676675

humanwhole-genome sequencing

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Cancer BiologybioRxivPreprintJan 31, 2025

Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinoma

Hella Anna Bolck, Ede Migh, András Kriston…·Holger Moch

This study uses AI-based image analysis and multi-omics profiling to link morphological features with molecular changes in ccRCC, identifying unique molecular profiles in aggressive rhabdoid tumors.

1 citation

humanscRNA-seq

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