BioinformaticsbioRxivPreprint
RIPPLET: Mutation-Only Gene and Pathway Profiling for Precision Oncology
Fabius Wiesmann, Cassandra Litchfield, Maud Mayoux…·Bettina Sobottka
RIPPLET converts somatic DNA variants into gene-impact scores and pathway-perturbation profiles, outperforming multi-omic tools in identifying cancer drivers and predicting drug response without RNA data.
DOI 10.1101/2025.09.17.676675