Burkhard Becher

This study shows that GM-CSF signaling in CCR2+ cells is essential for killing Aspergillus fumigatus and host survival during pulmonary infection.

This study identifies PD-L2's role on dendritic cells in restraining CD8+ T cell immunity in tumors, showing distinct functions from PD-L1 and suggesting therapeutic implications for PD-L2 blockade.

This study identifies altered follicular immunity and interferon hyperactivity in Down syndrome through single-cell and spatial profiling of human tonsils.

The paper identifies a fibroblast-IL-7 feedback loop that promotes immunosuppressive monocyte-derived cells, which restrain CD4+ T cell responses during infection.

This study shows IL-12R signaling sustains T-bet in Treg cells, promoting type 1 specialization and enhancing suppressive function against Th1 responses.

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

The paper identifies chemoresistant cell populations in pediatric AML that improve risk prediction and reveal therapeutic targets for high-risk patients.

RIPPLET converts somatic DNA variants into gene-impact scores and pathway-perturbation profiles, outperforming multi-omic tools in identifying cancer drivers and predicting drug response without RNA data.

The paper identifies CD4 memory T cell networks that form therapy-responsive immune niches in colorectal cancer liver metastases, determining chemotherapy response.

This study identifies meningeal monocyte-derived macrophages as drivers of progressive multiple sclerosis using single-cell and spatial transcriptomics.

The paper shows that T cell-derived IFN-γ suppresses TFH differentiation and antibody responses by acting through dendritic cells, not directly on CD4+ T cells.

This study identifies early yolk sac-derived macrophages in the pituitary gland and shows their role in hormonal regulation and post-pubertal gene expression.

This study shows that dermal macrophages can maintain functional diversity without monocyte replenishment, but require monocytes during bacterial infections.

The paper identifies CD226high macrophages derived from MDP monocytes as a new myeloid cell type involved in lipid metabolism regulation across tissues.

The paper identifies monocyte-derived cells as the primary source of ROS-mediated oxidative tissue damage in neuroinflammation, distinct from microglia.

The paper identifies transcription factors and chromatin regulators critical for haemato-endothelial mesoderm formation using CRISPR-Cas9 screens in mouse embryonic stem cells.

This study identifies IL-12 as the main driver of neuroinflammation in Alzheimer's disease by affecting oligodendrocyte survival and neuronal homeostasis in a mouse model.

This study shows that pericytes restrict immune cell entry into the CNS by maintaining immune quiescence of brain endothelial cells, and their deficiency leads to increased leukocyte infiltration and severe neuroinflammation.

This study shows that reducing CSF-2 in Csf1r+/- mice rescues behavioral and histopathological deficits in ALSP by preventing microgliosis and transcriptomic changes, suggesting CSF-2 as a therapeutic target.