Author

Paulina Troncoso-Escudero

Universidad MayorORCID 0000-0001-9458-274XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Claudio A. HetziD· 2 shared Lars PlateiD· 2 shared Marisol Cisternas-OlmedoiD· 2 shared Paula García-Huerta· 2 shared R. Luke WisemaniD· 2 shared René L. VidaliD· 2 shared S. Pablo SardiiD· 2 shared Alberto J. M. MartíniD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Claudio A. HetzORCID

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2 papers

Recent·Most cited

NeuroscienceMolecular TherapyPeer-reviewedFeb 5, 2021

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration

René L. Vidal, Denisse Sepúlveda, Paulina Troncoso-Escudero…·Claudio A. Hetz

This study shows that forcing dimerization between ATF6f and XBP1s enhances UPR activity, reducing protein aggregation in neurodegenerative disease models.

42 citations

humanmouse

𝕏 PostBluesky

NeuroscienceActa NeuropathologicaPeer-reviewedJul 8, 2020

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

Paula García-Huerta, Paulina Troncoso-Escudero, Di Wu…·Claudio A. Hetz

This study identifies IGF2 as a disease modifier that reduces intracellular protein aggregates by promoting their extracellular disposal in Huntington's disease models.

70 citationstop 3%

humanmouse

𝕏 PostBluesky