Yung‐Heng Chang

Endogenous Retroviruses and TDP-43 Proteinopathy Form a Sustaining Feedback to Drive the Intercellular Spread of Neurodegeneration

The paper shows that endogenous retroviruses and TDP-43 proteinopathy form a feedback loop that drives the spread of neurodegeneration in a Drosophila model.

Intercellular viral spread and intracellular transposition of Drosophila gypsy

This study shows Drosophila gypsy retrotransposon can replicate via both intracellular retrotransposition and intercellular viral spread, depending on the presence of its envelope protein.

Cellular labeling of endogenous virus replication (CLEVR) reveals de novo insertions of the gypsy endogenous retrovirus in cell culture and in both neurons and glial cells of aging fruit flies

The paper introduces CLEVR, a method to detect gypsy retrovirus replication in Drosophila, showing increased replication in aging flies and when RNAi is disrupted.