Author

Brenna A. Rheinheimer

University of ArizonaORCID 0000-0001-9461-4967Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Kirsten H. LimesandiD· 3 shared Alejandro Martinez ChiblyiD· 1 shared Kristy E. GilmaniD· 1 shared Lauren G. Buss· 1 shared Lauren N. MeeksiD· 1 shared Mary C. PasqualeiD· 1 shared Matthew P. HoffmaniD· 1 shared NIDCD/NIDCR Genomics and Computational Biology Core· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 17 mutual co-author links

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3 shared papersMolecular Biology

Kirsten H. LimesandORCID

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3 papers

Recent·Most cited

Radiation-Induced Changes in Energy Metabolism Result in Mitochondrial Dysfunction in Salivary Glands

Lauren G. Buss, Brenna A. Rheinheimer, Kirsten H. Limesand

This study investigates radiation-induced changes in energy metabolism in salivary glands, finding altered glycolytic and oxidative phosphorylation rates and mitochondrial dysfunction over time.

Scientific Reports · Jan 8, 2024Peer-reviewedMolecular Biology

AMPK activation restores salivary function following radiation treatment

Rachel K. Meyer, Kristy E. Gilman, Brenna A. Rheinheimer, Lauren N. Meeks, Kirsten H. Limesand

This study shows that AMPK activators like AICAR and metformin reverse radiation-induced salivary gland dysfunction by restoring cell polarity and differentiation markers.

Journal of Dental Research · Feb 1, 2023Peer-reviewedMolecular Biology

scRNAseq of healthy and irradiated mouse parotid glands highlights crosstalk between immune and secretory cells during chronic injury

Brenna A. Rheinheimer, Mary C. Pasquale, NIDCD/NIDCR Genomics and Computational Biology Core, Kirsten H. Limesand, Matthew P. Hoffman, Alejandro Martinez Chibly

The paper uses scRNA-seq to analyze chronic irradiation effects on mouse parotid glands, identifying Etv1+ epithelial cells and transcriptional changes in immune and secretory cells.

bioRxiv · Nov 26, 2022 · PreprintMolecular Biology