Author

Alejandro Martinez Chibly

GenentechORCID 0000-0001-7747-4990Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Minyi ShiiD· 2 shared Yangmeng WangiD· 2 shared Yuxin LiangiD· 2 shared Aaron T. L. LuniD· 1 shared Adrian Waddell· 1 shared Aleksander ChlebowskiiD· 1 shared Antonina HafneriD· 1 shared Anwesha DeyiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Minyi ShiORCID

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3 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedJun 8, 2026

Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells

Eun‐Jung Kim, Dexter X. Jin, Alejandro Martinez Chibly…·Meng He

The paper identifies synthetic lethality between POLE exonuclease deficiency and high aneuploidy in cancer cells, suggesting POLE inhibition as a therapeutic strategy for aneuploid tumors.

DOI 10.1158/0008-5472.can-25-3977

humanwhole-genome sequencing

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BioinformaticsNature CommunicationsPeer-reviewedAug 2, 2025

Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell state

Tomasz Włodarczyk, Aaron T. L. Lun, Diana H. Wu…·Xiaosai Yao

Epiregulon infers single-cell TF activity using ATAC-seq and RNA-seq to predict drug response and identify drivers of cell state.

13 citations

humanscATAC-seq

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Molecular BiologybioRxivPreprintNov 26, 2022

scRNAseq of healthy and irradiated mouse parotid glands highlights crosstalk between immune and secretory cells during chronic injury

Brenna A. Rheinheimer, Mary C. Pasquale, NIDCD/NIDCR Genomics and Computational Biology Core…·Alejandro Martinez Chibly

The paper uses scRNA-seq to analyze chronic irradiation effects on mouse parotid glands, identifying Etv1+ epithelial cells and transcriptional changes in immune and secretory cells.

2 citations

mousescRNA-seq

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