Systems BiologybioRxivPreprint
Laboratory evolution of Mycobacterium smegmatis in the presence of a fluoroquinolone leads to extreme drug resistance phenotype through the over-expression of Msmeg_5659-61 efflux pump.
Deepika Rai, Priyanka Padwal, Priyanka Purkayastha, Sarika Mehra
This study shows that laboratory evolution of Mycobacterium smegmatis under fluoroquinolone pressure leads to extreme drug resistance through overexpression of an efflux pump, without mutations in drug target genes.
DOI 10.1101/2022.12.18.519879