Sarika Mehra

This study defines the physiological limits of efflux-mediated drug resistance in mycobacteria through adaptive evolution experiments, revealing a resistance ceiling and metabolic rewiring as key factors.

This study uses adaptive laboratory evolution to show that Streptomyces coelicolor develops ciprofloxacin resistance via efflux pumps and increased antibiotic production, with cross-resistance and collateral sensitivity to other drugs.

This study identifies SCO4122 as a MarR regulator that activates the MFS transporter SCO4121 through substrate-dependent molecular mechanisms.

This study shows that laboratory evolution of Mycobacterium smegmatis under fluoroquinolone pressure leads to extreme drug resistance through overexpression of an efflux pump, without mutations in drug target genes.