ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity
Chiara Cassioli, Nagaja Capitani, Claire C. Staton…·Cosima T. Baldari
This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.
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