Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity
Chiara Cassioli, Nagaja Capitani, Claire C. Staton, Claudia Schirra, Francesca Finetti, Anna Onnis, Nadia Alawar, Szu-Min Tu, Ludovica Lopresti, Vanessa Tatangelo, Carmela Tangredi, Salvatore Valvo, Hsin‐Fang Chang, Annachiara Miccoli, Ewoud Bernardus Compeer, , Cosima T. Baldari
This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.
Proceedings of the National Academy of Sciences · Feb 4, 2025Peer-reviewedImmunology