Bruce R. Blazar

Keratinocyte VISTA attenuates UV light-induced skin injury by suppressing cutaneous type I interferon (IFN-I) response

This study identifies VISTA as a suppressor of UV-induced IFN-I responses in keratinocytes, reducing skin injury in mice and human cells.

Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K+ Supramolecular Attack Particles

This study identifies CD8-iTreg as potent anti-tumor effectors and GVHD suppressors through Granzyme-K+ supramolecular attack particles.

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

This study edits Cyclophilin A's C-terminus using CRISPR/Cas9 to create cell therapies resistant to cyclosporine and voclosporin, preserving function in immune suppression settings.

The role of VISTA engagement in limiting neutrophil-mediated inflammation

This study shows that agonist anti-VISTA antibodies reduce neutrophil inflammation by decreasing their peripheral accumulation and increasing liver cell death, improving arthritis in mice.

Single-chain nanobody inhibition of Notch and avidity enhancement utilizing the β-pore forming toxin Aerolysin

This study develops a Notch inhibitory nanobody and demonstrates a strategy to enhance its efficacy through fusion with an Aerolysin domain.

Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

Regulatory T cells crosstalk with tumor and endothelium through lymphotoxin signaling

This study identifies Treg-mediated lymphotoxin signaling that promotes tumor growth and metastasis by activating nonclassical NFκB pathways in tumor and endothelial cells, and shows that targeting this pathway can suppress tumor progression.