Deniz Kirik

This study shows that astrocytes in the substantia nigra pars compacta of A53T transgenic mice have more -synuclein aggregates and reactive morphology compared to wild-type mice.

The paper uses machine learning to analyze neuronal morphology in Parkinson's disease iPSC-derived neurons, identifying genotype-specific mitochondrial and lysosomal abnormalities.

This study compares dopamine and cortical neurons with PD mutations to identify cellular dysfunctions linked to different pathological phenotypes.

The paper develops and validates new immunoassays for quantifying total, phospho-Ser129, and aggregated alpha-synuclein in mouse brain tissue.

This paper demonstrates that sadCas9-mediated CRISPRi reduces alpha-synuclein expression in a humanized mouse model of Parkinson's disease, showing long-term downregulation and attenuated immune response.

This study uses CRISPRi to downregulate alpha-synuclein in a Parkinson's disease patient-derived model, reducing oxidative stress and mtDNA damage.

This study combines CRISPR/Cas9 gene editing with in vivo imaging to explore the impact of VMAT2 gene disruption on brain function and connectivity in rats.

The paper compares neurotoxicity of human A53T and mouse α-synuclein variants, finding mouse aSyn is less toxic due to C-terminal substitutions reducing membrane-induced aggregation and vesicle permeabilization.

This study shows that early viral delivery of GDNF improves survival and function of human stem cell grafts in Parkinson's disease models.

The paper demonstrates that alpha-synuclein aggregates spread interneuronally in an organotypic hippocampal slice model, independent of serine 129 phosphorylation.