Author

Jie Chen

University of WashingtonORCID 0000-0001-9609-669XUnclaimed ORCID profile · follow to get notified of new preprints

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Jie Chen15 papers · Nanjing Agricultural University

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:large language model· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Aiko MuraishiiD· 1 shared Anant MittaliD· 1 shared Andrew Hunt· 1 shared Cyrus M. HaasiD· 1 shared David BakeriD· 1 shared Harley PylesiD· 1 shared Jasper ButcheriD· 1 shared Jeremy G. KoobiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Aiko MuraishiORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintOct 20, 2026

✦ In-depth digest

Reliable and Efficient Agentic Protein Design with Toolset Harnessing

Jasper Butcher, Jie Chen, Andrew Hunt…·David Baker

Chaperone, a DataFrame-based framework and agent harness for protein design tools, cut tokens 86% and GPU-hours 64% while raising pass rate from 6% to 12%.

DOI 10.64898/2026.10.19.759896

protein structureprotein sequence

𝕏 PostBluesky