Harley Pyles

Chaperone, a DataFrame-based framework and agent harness for protein design tools, cut tokens 86% and GPU-hours 64% while raising pass rate from 6% to 12%.

This study shows that computationally designed proteins can template and confine hydroxyapatite mineralization, providing a framework for programmable protein-guided mineralization.

This study designs proteins to control the phase, form, and function of metal-carbonate materials, demonstrating their use as electrocatalysts for alkaline water splitting.

This paper designs twistless alpha-helical repeat proteins that inhibit ice recrystallization with activity comparable to native ice-binding proteins.

This paper identifies an unknown contaminant in protein samples using Cryo-EM and AI tools, leading to improved purification protocols.

The paper designs proteins that template mineralization of metal-oxides, showing they can guide hematite and ZnO growth under specific conditions.