Lukas Flatz

This study identifies genomic features, particularly copy-number alterations, that predict metastatic progression in melanoma and defines a six-gene signature associated with relapse.

The paper examines immune receptor clonality in melanoma-draining lymph nodes and finds that extreme high clonality is linked to immune dysfunction and poor survival.

The paper investigates immune cell senescence in melanoma patients and finds that non-responders to immunotherapy have higher senescence in immune cells compared to responders.