Tobias W. Sinnberg

This study identifies genomic features, particularly copy-number alterations, that predict metastatic progression in melanoma and defines a six-gene signature associated with relapse.

The paper examines immune receptor clonality in melanoma-draining lymph nodes and finds that extreme high clonality is linked to immune dysfunction and poor survival.

This study shows that constitutive IκBζ expression in melanoma promotes tumor growth and immunotherapy resistance by suppressing cytokine production and immune cell recruitment.