NW-flex: flexible-block sequence alignment for short tandem repeats
NW-flex improves STR read alignment by allowing flexible block contraction while maintaining alignment optimality and using minimal computational overhead.
Author
Cold Spring Harbor LaboratoryORCID 0000-0001-9684-2410Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
NW-flex improves STR read alignment by allowing flexible block contraction while maintaining alignment optimality and using minimal computational overhead.
Siran Li, Joan Alexander, Jude Kendall…·Dan Levy
This study introduces hybrid BAG-seq to analyze DNA and RNA from single nuclei in tumor samples, revealing genome-transcriptome interactions and tumor heterogeneity.
Dan Levy, Zihua Wang, Andrea B. Moffitt, Michael H. Wigler
This paper introduces a method to accurately measure microsatellite lengths by disrupting their tandem repeat structure, achieving error rates below one in a million.