Michael H. Wigler

This study introduces hybrid BAG-seq to analyze DNA and RNA from single nuclei in tumor samples, revealing genome-transcriptome interactions and tumor heterogeneity.

This paper introduces a method to accurately measure microsatellite lengths by disrupting their tandem repeat structure, achieving error rates below one in a million.

G-Graph is an interactive genomic scatter plot viewer designed for exploring numeric data and annotations across genomic positions, enabling researchers to analyze copy number profiles and identify deleterious variants.

The paper shows damaging de novo mutations in ASD are linked to impaired motor skills, independent of IQ, and proposes a new classification of phenotypic severity based on these associations.

The paper introduces muSeq, a protocol that uses mutational sequencing to improve count accuracy and long-range assembly from short-read data.

The paper identifies de novo intronic indels in autism target genes from simplex families and finds they contribute to at least 10% of simplex autism.