GenomicsiSciencePeer-reviewed
Recruitment of transcriptional effectors by Cas9 creates cis regulatory elements and demonstrates distance-dependent transcriptional regulation
Jubran Boulos, Arkadiy K. Golov, Nadav Keren…·Izhak Kehat
The paper shows that recruiting transcription factors to non-regulatory genomic sites can create enhancers or repressors, influencing gene expression at a distance with nonlinear dependence on site distance.
4 citations