Izhak Kehat

Hypertension-mediated cardiac fibrosis is a mechanical process initiated by smooth muscle cells

This study identifies smooth muscle cells as the primary initiators of hypertension-mediated cardiac fibrosis through ECM-dependent mechanical processes, independent of fibroblasts.

Dual Translational Control in Cardiomyocytes by Heterogeneous mTORC1 and Hypertrophic ERK Activation

This study identifies heterogeneous mTORC1 activity and a novel ERK-dependent pathway driving 4EBP1 phosphorylation in cardiomyocytes during hypertrophy, revealing dual translational control mechanisms.

Recruitment of transcriptional effectors by Cas9 creates cis regulatory elements and demonstrates distance-dependent transcriptional regulation

The paper shows that recruiting transcription factors to non-regulatory genomic sites can create enhancers or repressors, influencing gene expression at a distance with nonlinear dependence on site distance.

Single molecule imaging reveals extracellular signal-regulated kinases dependent signal responsive spatial regulation of translation in cardiomyocytes

This study uses single-molecule imaging to show ERK-dependent spatial regulation of translation in cardiomyocytes, with translation sites near Z-lines and dynamic movement along microtubules.