Profiling drug sensitivity of leukemic stem cells via bulk-to-single-cell deconvolution
Alexandre Coudray, Romain Forey, Benjamı́n Béjar, Filipe Martins, Joana Carlevaro-Fita, Shaoline Sheppard, Sandra Eloise Offner, Gioele La Manno, Guillaume Obozinski, Didier Trono
The paper develops a machine learning framework to estimate cell subtype-specific drug sensitivity from bulk data, applying it to leukemia datasets to identify potential therapeutic targets.
bioRxiv · May 10, 2023 · PreprintBioinformatics