Alexandre Coudray

This study identifies evolutionarily recent transcription factors that influence human cell cycle regulation by affecting gene expression and replication timing.

The paper quantifies TE-mediated cis-regulation using statistical learning, showing TE-embedded CREs influence gene expression and can be predicted from RNA-seq data.

This study examines the genetic features and genomic targets of human KRAB-Zinc Finger Proteins, revealing their role in regulating transposable elements and their evolutionary significance.

The paper develops a machine learning framework to estimate cell subtype-specific drug sensitivity from bulk data, applying it to leukemia datasets to identify potential therapeutic targets.

The paper identifies KZFP:TE transcriptional profiles and TE-derived promoters in the developing human brain, showing their role in neurogenesis.

The paper analyzes the evolutionary dynamics of KRAB zinc finger protein-coding genes in humans, finding that older genes show stronger negative selection while younger genes exhibit more genetic variation and less constraint.

This study identifies DPPA2 and DPPA4 as essential for activating Dux and LINE-1 transcription, which is critical for zygotic genome activation in mouse embryos.