Sandra Eloise Offner

The paper identifies functional roles of human KZFPs through overexpression screening and integrative analysis, revealing diverse mechanisms in cellular homeostasis.

The paper shows ZNF93, a primate-specific protein, regulates APOBEC3B and influences cancer progression by affecting DNA synthesis and genomic stability.

This study identifies evolutionarily recent transcription factors that influence human cell cycle regulation by affecting gene expression and replication timing.

The paper identifies a noncanonical role for KZFPs in restricting TE-derived regulatory elements to maintain cell-type identity, independent of TRIM28.

This study shows that SCAN domain zinc-finger proteins bind transposon sequences and anchor nucleosomes, affecting chromatin structure and regulatory states.

The paper shows that a transposable element-derived domain in KRAB zinc-finger proteins enables new transcription factor functions through trimerization and condensate formation.

This study identifies ZNF274's role in anchoring lineage-specific gene clusters within repressive perinucleolar compartments, revealing its impact on chromatin structure and gene regulation.

This study examines the genetic features and genomic targets of human KRAB-Zinc Finger Proteins, revealing their role in regulating transposable elements and their evolutionary significance.

The paper develops a machine learning framework to estimate cell subtype-specific drug sensitivity from bulk data, applying it to leukemia datasets to identify potential therapeutic targets.

This study shows that DUX regulates transcription during early embryonic cell divisions in mice but is not strictly essential for embryogenesis.