Dongqiang Zeng

Python toolkit chains RNA-seq quantification, six-method tumour microenvironment (TME) profiling, SpecHLA typing and TRUST4 repertoire analysis with AI agents; TME outputs match R implementations (Spearman 0.986 to ~1.0).

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

IOBR is a computational tool that integrates multi-omics data to analyze tumor microenvironment and signatures, enabling batch analysis and comparison of immunotherapy-related features.