Cynthia J. Donaldson

This study uses CRISPR-Cas9 screening to identify microproteins regulating adipocyte proliferation and lipid metabolism in mice, revealing a novel mouse-specific microprotein involved in adipocyte differentiation.

The paper identifies and characterizes small ORFs and microproteins in adipose cells, showing their metabolic relevance and potential roles in obesity and inflammation.

The paper improves smORF annotation by integrating de novo transcriptome assembly and Ribo-Seq, identifying thousands of novel translated smORFs in human cell lines and highlighting their functional potential.