Author

Joan M. Vaughan

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

Alan SaghatelianiD· 3 shared Antônio F. M. PintoiD· 2 shared Cynthia J. DonaldsoniD· 2 shared Eduardo Vieira de SouzaiD· 2 shared Aaron J. MerceriD· 1 shared Alex Simon· 1 shared Ami Siddharth BhattiD· 1 shared Andrew J. WhittleiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

Alan SaghatelianORCID

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Author profile →

3 papers

Recent·Most cited

CRISPR-Cas9 Screening Reveals Microproteins Regulating Adipocyte Proliferation and Lipid Metabolism

Victor J. Pai, Huanqi Shan, Cynthia J. Donaldson, Joan M. Vaughan, Eduardo Vieira de Souza, Carolyn O’Connor, Michelle Liem, Antônio F. M. Pinto, Jolene K. Diedrich, Alan Saghatelian

This study uses CRISPR-Cas9 screening to identify microproteins regulating adipocyte proliferation and lipid metabolism in mice, revealing a novel mouse-specific microprotein involved in adipocyte differentiation.

Proceedings of the National Academy of Sciences · Aug 7, 2025Peer-reviewedCell Biology

Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness of Enterococcus faecalis

Soumaya Zlitni, Sierra Bowden, Hila Sberro, Marcelo D. T. Torres, Joan M. Vaughan, Antônio F. M. Pinto, Yishay Pinto, Daniel Fernández, Hannes Luc Röst, Alan Saghatelian, César de la Fuente‐Núñez, Ami Siddharth Bhatt

This study identifies two quorum-sensing systems in E. faecalis that regulate purine biosynthesis, enhancing its pathogenicity in macrophages and murine infections.

bioRxiv · Aug 13, 2024 · PreprintMicrobiology

Profiling Mouse Brown and White Adipocytes to Identify Metabolically Relevant Small ORFs and Functional Microproteins

Thomas Farid Martinez, Sally Lyons‐Abbott, Angie L. Bookout, Eduardo Vieira de Souza, Cynthia J. Donaldson, Joan M. Vaughan, Calvin J. Lau, Ariel Abramov, Arian F. Baquero, Karalee C. Baquero, Dave Friedrich, Justin N. Huard, Ray Davis, Bong-Chul Kim, Ty Koch, , Christopher A. Barnes

The paper identifies and characterizes small ORFs and microproteins in adipose cells, showing their metabolic relevance and potential roles in obesity and inflammation.

Cell Metabolism · Jan 1, 2023Peer-reviewedSystems Biology