MicrobiologyInfection and ImmunityPeer-reviewed
Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol
Ava Quezada, Kevin Lord, Cheldon Ann Alcantara…·Cheryl Y. M. Okumura
This study shows that Group A Streptococcus perforates macrophage phagolysosomes, releasing both host and bacterial proteins into the cytosol, which triggers inflammatory responses and contributes to disease pathology.
DOI 10.1128/iai.00199-26