Author

Jennifer L. Curcuru

New England Biolabs (United States)ORCID 0000-0001-9749-9802Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

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G. Brett RobbiD· 1 shared Megumu Yamada Mabuchi· 1 shared Paul YourikiD· 1 shared Ryan T. FuchsiD· 1 shared

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2019-2019 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperMolecular Biology

G. Brett RobbORCID

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1 paper

Recent·Most cited

Cas12a trans-cleavage can be modulated in vitro and is active on ssDNA, dsDNA, and RNA

Ryan T. Fuchs, Jennifer L. Curcuru, Megumu Yamada Mabuchi, Paul Yourik, G. Brett Robb

Once activated, Cas12a degrades RNA and double-stranded DNA in trans, not only single-stranded DNA, with the amount depending on buffer, guide RNA features and which ortholog is used.

bioRxiv · Apr 8, 2019 · PreprintMolecular Biology