Author

Ryan T. Fuchs

New England Biolabs (United States)ORCID 0000-0001-8238-6442Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

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Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

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G. Brett RobbiD· 1 shared Jennifer L. CurcuruiD· 1 shared Megumu Yamada Mabuchi· 1 shared Paul YourikiD· 1 shared

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2019-2019 · peak 1/yr

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1 shared paperMolecular Biology

G. Brett RobbORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintApr 8, 2019

Cas12a trans-cleavage can be modulated in vitro and is active on ssDNA, dsDNA, and RNA

Ryan T. Fuchs, Jennifer L. Curcuru, Megumu Yamada Mabuchi…·G. Brett Robb

Once activated, Cas12a degrades RNA and double-stranded DNA in trans, not only single-stranded DNA, with the amount depending on buffer, guide RNA features and which ortholog is used.

51 citations

DNA methylationCRISPR screen

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