Wen Ye

The paper introduces LetsACT, a multimodal integration platform that combines morphological, spatial, and transcriptomic data to analyze morpho-genetic variations in human cortical neurons associated with tumor infiltration.

This paper identifies intrinsic features that distinguish human and mouse cortical neurons, revealing significant differences in morphology, function, and separability across brain regions.

The paper introduces a collaborative platform augmented by AI for large-scale 3D neuron morphology reconstruction in mouse and human brains, showing its capability to generate tens of thousands of reconstructions.