Interleukin-27 is antiviral at the maternal-fetal interface.
Madeline S. Merlino, Briah Barksdale, Seble G. Negatu, Rebecca L. Clements, Taylor Miller-Ensminger, Alexandra H. Lopez, Sneha Ramesh Mani, Monica Ailawadi Mainigi, Christopher A. Hunter, Kellie A. Jurado
This study identifies IL-27 as an antiviral cytokine at the maternal-fetal interface, showing it restricts Zika virus infection in placental trophoblast organoids and mouse models.
bioRxiv · Apr 28, 2025 · PreprintMicrobiology