Seble G. Negatu

This study shows that acute paternal immune activation alters sperm small RNAs, which reprogram embryonic gene expression and enhance offspring survival from viral infection.

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

This study identifies IL-27 as an antiviral cytokine at the maternal-fetal interface, showing it restricts Zika virus infection in placental trophoblast organoids and mouse models.

The paper shows that in 3D forebrain organoids, neurons and neural progenitors use type I interferon signaling to limit viral spread through intercellular communication.

This study shows that type I interferon reduces extravillous trophoblast invasion and induces a preeclampsia-like gene signature in an organ-on-a-chip model of implantation.

The paper identifies antiviral immune responses in neural stem cells and shows how a neuropathogenic virus inhibits these responses in forebrain organoids.