Fan Wang

This study identifies 13 rare haplotypes associated with increased breast cancer risk using genome-wide haplotype-BCa association analysis in UK Biobank data, with partial generalizability in an independent cohort.

The paper identifies rare risk haplotypes associated with breast cancer that may misrepresent risk through common alleles, challenging the polygenic model.

SENIES is a deep learning predictor that identifies enhancers and their strength by integrating DNA shape features with sequence-derived features.

LocusFocus is a web tool that tests colocalization between GWAS and eQTL data to identify relevant genes and tissues for GWAS loci.

The paper identifies cancer-specific eQTLs by modeling genotype-tumor purity interactions in heterogeneous tumor gene expression data, showing most risk variants affect tumor microenvironment cells.