Wonjong Moon

Genome-wide Analysis of Rare Haplotypes Associated with Breast Cancer Risk: Discovery, Replication, and Generalizability Evaluation

This study identifies 13 rare haplotypes associated with increased breast cancer risk using genome-wide haplotype-BCa association analysis in UK Biobank data, with partial generalizability in an independent cohort.

Potential Misrepresentation of Inherited Breast Cancer Risk by Common Germline Alleles

The paper identifies rare risk haplotypes associated with breast cancer that may misrepresent risk through common alleles, challenging the polygenic model.

Genome-wide association studies reveal novel locus with sex-/therapy-specific fracture risk effects in childhood cancer survivors

The paper identifies a novel genetic locus associated with fracture risk in childhood cancer survivors, with effects specific to sex and therapy, using genome-wide association studies.

Generalizability of "GWAS hits" in clinical populations: Lessons from childhood cancer survivors

The paper evaluates the generalizability of GWAS findings in childhood cancer survivors and finds limited replication of meta-GWAS hits in these populations.