Xiaoping Du

This study standardizes the mouse MCAO stroke model by distinguishing ICA and PPA occlusion, showing 15-minute ICA occlusion balances infarction and survival best.

This study identifies PF4 as a key regulator of HSC aging, showing that PF4 deficiency accelerates aging and that PF4 supplementation can rejuvenate aged HSCs.

The paper identifies matrimeres as nanoscale mediators of tissue integrity, showing they can restore vascular integrity after injury and are reconstituted from fibronectin, DNA, and acidic conditions.

This study identifies transferrin as a clotting factor that modulates coagulation balance by interacting with clotting factors and antithrombin III, with implications for atherosclerosis.