Matthew R. Groves

This study enables the de novo biosynthesis of alpinetin in E. coli through directed evolution of a 5-O-methyltransferase, demonstrating its broad substrate specificity for O-methylated flavonoids.

This paper characterizes two fungal polyketide synthases that produce substituted 2-quinolones and (thio)coumarins, demonstrating their potential for biocatalytic drug discovery.