PathologybioRxivPreprint
VGLL4 promotes thoracic aortic aneurysm and dissection by disrupting extracellular matrix homeostasis via WISP1-mediated TIMP3/MMP9 imbalance
Lu Ding, Jianshe Ma, Pinmeng Diao…·Yongyu Wang
This study identifies VGLL4 as a mechanosensitive regulator of TAAD by disrupting ECM homeostasis through the WISP1-TIMP3/MMP9 axis.
DOI 10.64898/2026.08.26.747433