Author

Lu Ding

Wenzhou Medical UniversityORCID 0000-0002-1966-4080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Peifeng JiniD· 2 shared Xiufang CheniD· 2 shared Yongyu WangiD· 2 shared Adolfo Garcı́a-OcañaiD· 1 shared Chelsea Jang· 1 shared Congkuo DuiD· 1 shared Debbie C. ThurmondiD· 1 shared Erika M. McCown· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPathology

Peifeng JinORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Role of Uridine Phosphorylase 1 (UPP1) in Pancreatic β-Cell Physiology and Its Dysregulation in Obesity and Type 2 Diabetes

YUNQIAN PENG, Lu Ding, Qiutang Xiong, Ling Fu, Chelsea Jang, Yin Wang, Ignacio Norambuena‐Soto, Kevin Wang, Gemin Lu, Erika M. McCown, Eunjin Oh, Lin Tan, Jeffrey Scott Isenberg, Ping Wang, Philipp E. Scherer, , Yingfeng Deng

This study investigates the role of UPP1 in β-cell function and shows that UPP1 deficiency impairs uridine-potentiated GSIS and MAPK activation in mice and humans.

bioRxiv · Sep 28, 2026 · PreprintMolecular Biology

VGLL4 promotes thoracic aortic aneurysm and dissection by disrupting extracellular matrix homeostasis via WISP1-mediated TIMP3/MMP9 imbalance

Lu Ding, Jianshe Ma, Pinmeng Diao, Runze Dong, Yutao Tong, Jinbiao Lai, Yuyue Shao, Minjie Hu, Jiwen Yang, Peifeng Jin, Xiaofang Fan, Yongsheng Gong, Congkuo Du, Xuejiao Chen, Xiufang Chen, , Yongyu Wang

This study identifies VGLL4 as a mechanosensitive regulator of TAAD by disrupting ECM homeostasis through the WISP1-TIMP3/MMP9 axis.

bioRxiv · Aug 30, 2026 · PreprintPathology

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang

This study uses patient-specific iPSCs to model thoracic aortic dissection, revealing VSMC dysfunction and extracellular matrix dysregulation linked to COL4A2 mutations and TGF-β signaling.

Stem Cells International · Jan 1, 2025Peer-reviewedPathology