NeurosciencebioRxivPreprint
NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer's disease
Fan Fan, Prince Joshi, Xiaojie Liu…·Xuelin Lou
This paper identifies Sarm1 as a driver of synapse degeneration and memory loss in Alzheimer's disease by showing its deletion prevents synapse loss and cognitive decline in mouse models.
DOI 10.64898/2025.12.21.695860